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Posted By: Sanjana Member Level: Gold Posted Date: 14 Jun 2008
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2005 Molecular biology Question paper
Molecular Biology Module May 2005
SCHOOL OF BIOLOGY
UNIVERSITY OF ST ANDREWS
MOLECULAR BIOLOGY
MODULE BL1201
2004-2005
DEGREE EXAMINATION
May 2005
Time available: 2 hours
PLEASE WRITE YOUR MATRICULATION NUMBER ON EVERY SHEET, INCLUDING THE QUESTIONS YOU DO NOT ANSWER
NAME: ………………………………………………………………
MATRICULATION NUMBER:…………………………………….
ANSWER EIGHT QUESTIONS OUT OF NINE
All questions carry equal value.
Molecular Biology Module May 2005 Page 2
MATRICULATION NUMBER:
……………………………………………………………………………..
1. Several amino acids have side chains in which the ionisation state can be
influenced by pH. Describe one protein whose function depends on such an
amino acid.
If you continue overleaf please tick this box
Molecular Biology Module May 2005 Page 3
MATRICULATION NUMBER:
……………………………………………………………………………..
2. With reference to at least one example, outline the importance of glycine
(R=H) in protein structure and function.
If you continue overleaf please tick this box
Molecular Biology Module May 2005 Page 4
MATRICULATION NUMBER:
……………………………………………………………………………..
3. Discuss the use of antibiotic resistance and the lac-Z system for the selection of bacterial colonies following transformation by a plasmid.
If you continue overleaf please tick this box
Molecular Biology Module May 2005 Page 5
MATRICULATION NUMBER:
……………………………………………………………………………..
4. ANSWER PARTS a AND b.
a. Summarise the roles of EACH of the following ‘key players’ in the process of DNA replication.
Topoisomerase:
DNA helicase:
DNA polymerase:
DNA ligase:
RNA primase:
Single strand binding proteins:
b. Write short notes on the role of telomeres.
If you continue overleaf please tick this box
Molecular Biology Module May 2005 Page 6
MATRICULATION NUMBER:
……………………………………………………………………………..
5. List the factors involved in the change from inactive to active chromatin.
If you continue overleaf please tick this box
Molecular Biology Module May 2005 Page 7
MATRICULATION NUMBER:
……………………………………………………………………………..
6. Describe briefly the functions of THREE of the following:
a. the TATA-binding protein.
b. small nuclear ribonucleoprotein particles (snRNPs).
c. transfer RNA (tRNA).
d. the signal recognition particle (SRP).
If you continue overleaf please tick this box
Molecular Biology Module May 2005 Page 8
MATRICULATION NUMBER:
……………………………………………………………………………..
7. Outline the scientific arguments for AND against sequencing the entire human genome.
If you continue overleaf please tick this box
Molecular Biology Module May 2005 Page 9
MATRICULATION NUMBER:
……………………………………………………………………………..
8. Describe the molecular details of how antibody diversity is generated.
If you continue overleaf please tick this box
Molecular Biology Module May 2005 Page 10
MATRICULATION NUMBER:
……………………………………………………………………………..
9. Write brief notes on TWO of the following:
a. Lymphocytes
b. Immunoglobulin A (IgA)
c. The different types of nucleic acid found in viruses
d. Innate immunity
e. Bacterial cell walls.
If you continue overleaf please tick this box
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