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Posted By: Sanjana Member Level: Gold Posted Date: 14 Jun 2008
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2005 Molecular biology sep05 Question paper
Molecular Biology Module September 2005
SCHOOL OF BIOLOGY
UNIVERSITY OF ST ANDREWS
MOLECULAR BIOLOGY
MODULE BL1201
2004-2005
DEGREE EXAMINATION
September 2005
Time available: 2 hours
PLEASE WRITE YOUR MATRICULATION NUMBER ON EVERY SHEET, INCLUDING THE QUESTIONS YOU DO NOT ANSWER
NAME: ………………………………………………………………
MATRICULATION NUMBER:……………………………………
ANSWER EIGHT QUESTIONS
All questions carry equal value.
Molecular Biology Module September 2005 Page 2
MATRICULATION NUMBER:
……………………………………………………………………………..
1. Why are alpha-helix and beta-sheet such prevalent forms of secondary
structure in proteins?
If you continue overleaf please tick this box
Molecular Biology Module September 2005 Page 3
MATRICULATION NUMBER:
……………………………………………………………………………..
2. Outline the mechanism by which ribonuclease cleaves RNA, emphasising the importance of the tertiary structure of the enzyme.
If you continue overleaf please tick this box
Molecular Biology Module September 2005 Page 4
MATRICULATION NUMBER:
……………………………………………………………………………..
3. Give a brief overview of the key experiments carried out by TWO of the following research groups, summarizing the protocols used and the conclusions drawn:
a. Frederick Griffith
b. Hershey and Chase
c. Meselson and Stahl.
If you continue overleaf please tick this box
Molecular Biology Module September 2005 Page 5
MATRICULATION NUMBER:
……………………………………………………………………………..
4. Outline the three mechanisms that correct or minimize errors in DNA replication, and then discuss the different types of point mutation, and their four possible outcomes.
If you continue overleaf please tick this box
Molecular Biology Module September 2005 Page 6
MATRICULATION NUMBER:
……………………………………………………………………………..
5. With the aid of diagrams, describe the steps involved in RNA splicing.
If you continue overleaf please tick this box
Molecular Biology Module September 2005 Page 7
MATRICULATION NUMBER:
……………………………………………………………………………..
6. Describe briefly the functions of THREE of the following:
a. histones
b. heterochromatin
c. RNA polymerase II
d. ribosomes.
If you continue overleaf please tick this box
Molecular Biology Module September 2005 Page 8
MATRICULATION NUMBER:
……………………………………………………………………………..
7. Write notes on the following
a. expressed sequence tag databases
b. automated DNA sequencing
c. The scientific significance of Dolly the sheep.
If you continue overleaf please tick this box
Molecular Biology Module September 2005 Page 9
MATRICULATION NUMBER:
……………………………………………………………………………..
8. Write brief notes on TWO of the following:
a. MHC molecules
b. Prions
c. IgE
d. Malaria infection
e. Principals of vaccination.
If you continue overleaf please tick this box
Molecular Biology Module September 2005 Page 10
MATRICULATION NUMBER:
……………………………………………………………………………..
9. Describe the generation of an adaptive immune response to a virus infection.
If you continue overleaf please tick this box
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