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Posted By: santosh kumar kanugula Member Level: Gold Posted Date: 03 Jul 2008
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2007 Jawaharlal Nehru Technological University B.Tech Biotechnology BIO PHARMACEUTICAL TECHNOLOGY Question paper
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Code No: RR412303 Set No. 1
IV B.Tech I Semester Supplementary Examinations, February 2007
BIO PHARMACEUTICAL TECHNOLOGY
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
? ? ? ? ?
1. What are antimalarial drugs? Give structure and uses of the following
(a) Quinine
(b) Trimethoprim
(c) Chloroquine
(d) Amodiaquine. [4+3+3+3+3]
2. (a) How are ionic / ionizable drugs absorbed
(b) Buffered aspirin tablets are more suitable than sodium salt form of aspirin
why? [8+8]
3. In contrast to zero order process, the half-life of a first-order process is considered to
be an important Pharmacokinetic parameter, why? Explain with suitable reasons?
[16]
4. What are the different types of reactions involved in the case of bulk drug manu-
facturing. [16]
5. Write about different stages involved in sugar coating. [16]
6. What is GMP and how does it assure the quality of drug product? [16]
7. Write the synthesis properties and uses of ascorbic acid. [16]
8. Describe about the therapeutic importance of hormones, give examples? [16]
? ? ? ? ?
1 of 1
Code No: RR412303 Set No. 2
IV B.Tech I Semester Supplementary Examinations, February 2007
BIO PHARMACEUTICAL TECHNOLOGY
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
? ? ? ? ?
1. How many types of licenses can be issued for the manufacture of drugs? Describe
the general procedure for obtaining a license stating the conductions to be satisfied.
[16]
2. Describe various theories that explain drug dissolution. [16]
3. (a) Define Pharmacokinetics. Name and define the three pharmacokinetic para-
meters that describe a typical plasma level - time curve.
(b) What are the various pharamcodynamic parameters? [8+8]
4. (a) Describe the Laboratory filtration equipment and their usage?
(b) What is cake filtration ? Describe the cake filtration process in the bulk drug
manufacturing industry. [8+8]
5. Write about different stages involved in sugar coating. [16]
6. What is GMP and how does it assure the quality of drug product? [16]
7. Indicate the importance of vitamins B1, B2, D and E, what are the sources of these
vitamins. [16]
8. Differentiate between non-steroidal and steroidal contraceptives? Write about non-
steroidal (or) synthetic Estrogens. [16]
? ? ? ? ?
1 of 1
Code No: RR412303 Set No. 3
IV B.Tech I Semester Supplementary Examinations, February 2007
BIO PHARMACEUTICAL TECHNOLOGY
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
? ? ? ? ?
1. (a) Describe the patents and designs act? Describe in brief the procedure for
obtaining a patent?
(b) What is meant by “piracy of registered design” and reciprocal arrangements
under the designs act? Define the term “patent” and “invention”. [8+8]
2. (a) How are ionic / ionizable drugs absorbed
(b) Buffered aspirin tablets are more suitable than sodium salt form of aspirin
why? [8+8]
3. (a) Why are first-order processes said to follow linear kinetics?
(b) Quote the examples of zero-order rate processes. [8+8]
4. (a) How the PH is controlled in the manufacture of bulk drugs? Explain with
examples.
(b) How the temperature is controlled in the case of bulk drug manufacturing.
explain with examples. [8+8]
5. Write about different stages involved in sugar coating. [16]
6. Write about the control and assurance of manufacturing practices involved for drug.
[16]
7. Write the synthesis properties and uses of ascorbic acid. [16]
8. Write the classification of antibiotics and describe about the production of penicillin
and their therapeutic importance? [16]
? ? ? ? ?
1 of 1
Code No: RR412303 Set No. 4
IV B.Tech I Semester Supplementary Examinations, February 2007
BIO PHARMACEUTICAL TECHNOLOGY
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
? ? ? ? ?
1. (a) Describe the standers of weight and measures act?
(b) Briefly discuss the provisions of the insecticides Act regarding the import,
manufacture, transport, distribution, and use of insecticides? [8+8]
2. What are the various mechanisms for drug-drug interactions in the GIT (Gastro
Interstinal Track)? Describe in detail. [16]
3. (a) Define Pharmacokinetics. Name and define the three pharmacokinetic para-
meters that describe a typical plasma level - time curve.
(b) What are the various pharamcodynamic parameters? [8+8]
4. What are the parameters used in the manufacture of bulk drugs? How the para-
meters are controlled. [16]
5. (a) Write about different methods of film coating.
(b) What are the objectives of the tablet coating and list out different stages of
sugar coating. [8+8]
6. What is GMP and how does it assure the quality of drug product? [16]
7. (a) What are laxatives? How they differs from analgesics?
(b) What are vitamins? How they differ from Hyperosmotic laxatives? [8+8]
8. (a) How Laxatives differ from hormones. Explain with examples.
(b) How non-steroidal contraceptives differ from Antibiotics. Explain with exam-
ples. [8+8]
? ? ? ? ?
1 of 1
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