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Posted By: giridhar narayan Member Level: Diamond Posted Date: 07 Feb 2008
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2002 Calicut University BIOCHEMISTRY – Paper I, FIRST PROFESSIONAL M.B.B.S DEGREE EXAMINATION, SEPTEMBER 2002 Question paper
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FIRST PROFESSIONAL M.B.B.S DEGREE EXAMINATION, SEPTEMBER 2002
BIOCHEMISTRY – Paper I
(New Scheme)
Time: Three Hours Maximum: 50 marks
Note:1.
Answer Sections A and B in separate answerbooks.
2. Attempt all questions.
3. Read the questions carefully and give specific answers avoiding
unnecessary details.
4. The Multiple Choice Questions (M.C.Q) should be answered in
the response sheet provided along with the Question Paper. The
M.C.Q. Should be answered first. The response sheet should be
handed over to the Invigilator at the close of ten minutes.
Section A
1. Give the reactions of citric acid cyclea long with its importance and energetics.
(6+2+2 = 10 marks)
2. Write briefly on:
(a) Formation of ketone bodies and their utilization.
(b) Major fate of ammonia produced in human body.
(2x5 = 10 marks)
3. Multiple Choice Questions (separate sheet attached) (5 marks)
Section B
4. (a) Write briefly on competitive inhibition.
(b) How is iron absorbed from the GI Tract?
(c) Define oxidative phosphorylation. Name any four uncouplers of oxidative
phosphorylation.
(d) Write briefly on hepatic jaundice.
(e) Write briefly on importance of dietary fibres. (5x3 = 15 marks)
5. (a) What is the diagnostic importance of serum LDH?
(b) Mention the composition of any two glycerophospholipids with their functions.
(c) Write briefly on any two glycogen storage diseases.
(d) Write briefly on Phenylketonuria.
(e) Write briefly on detoxification by conjugation. (5x2 = 10 marks)
3. MULTIPLE CHOICE QUESTIONS
BIOCHEMISTRY – Paper I
Time: 10 Minutes Maximum: 5 marks
Note:1.
Do not write anything on the question paper.
2. Write your register number on the anser sheet provided.
3. Select the appropriate answer and encircle the alphabet against each
question in the answer sheet provided.
4. In the answer sheet enter the total number of your answers in the
appropriate box provided.
5. Each question carries ½ mark.
1. The amino acid which has maximum buffering capacity at physiological pH is:
(A) Arginine (B) Alanine
(C) Histidine (D) Glutamic acid
2. Iodoacetate inhibits enzyme by reacting with whcih particular group at the active site
of the enzyme?
(A) Amide. (B) Sulfhydry1
(C) Carboxy1. (D) Imidazole.
3. The glycosidic linkage seen in lactose is:
(A) Alpha 14
(B) Beta 14
(C) Beta 16
(D) Alpha 16
4. In an immunoglobulin molecule, the antigen binding capacity resides at the:
(A) Constant region (B) Variable region
(C) Fe (fraction crystallisable) region. (D) J (joining) piece.
5. Muscle glycogen will not serve as a precursor of blood sugar because:
(A) Phosphorylase enzyme is absent in muscle.
(B) Receptor for glucagon is absent in muscle.
(C) Glucose = 6 = phosphatase enzyme is absent in muscle.
(D) Glycogen is converted to lactic acid in muscle.
6. The rate limiting enzyme of de novo synthesis of fatty acids is:
(A) Acetyl CoA transacylase. (B) Acetyl CoA carboxylase.
(C) Acetyl CoA dehydrogenase (D) BHydroxy
acy1 CoA dehydrogenase.
7. Hypercholesterolemia is seen in the following condiitions except:
(A) Uncontrolled diabetes mellitus (B) Thyrotoxicosis
(C) Nephrotic syndrome. (D) Obstructive jaundice
8. Blood urea level is markedly increased in:
(A) Liver diseases (B) Renal diseases
(C) Cardiac diseases (D) Protein intake.
9. Negative nitrogen balance is observed in:
(A) Pregnancy (B) Chronic fever
(C) Growth period (D) Convalescence.
10.Which of the following statement is most appropriate with regard to BenceJones
Proteins?
(A) It is seen in urine of 80% cases of multiple myeloma.
(B) It gives a positive Benedict's test in urine.
(C) It is precipitated when heated between 45° and 60 ° centigrade.
(D) If present in urine, prognosis is better.
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