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Use of Dipivefrine in glaucoma

Date: 14 Mar 2016   Posted By: Debashis Nanda     Group: Doctors    Category: Ophthalmologist   

Dipivefrine being a nonselective alpha agonist, it should cause mydriasis and thereby resist the outflow while not promoting it.But it has beta agonistic actions too. How does dipivefrine cause the increase in uveosacral and trabecular outflow?
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Author: Reena Upadhya    21 Jul 2016      Member Level: Silver     Points : 4  (Rs 4)    Voting Score: 0

Dipivefrine is a drug belonging to epinephrine group. It is used in the treatment of glaucoma. It penetrates cornea on application. It then gets hydrolyzed. It helps to reduce intraocular pressure by increasing uveo-scleral outflow. This is through alpha-1 and alpha-2 mediated action. It is responsible to decrease aqueous products. It also increases trabecular outflow. This is mainly by beta-2 mediated action.

Dipivefrine reduces intraocular pressure by acting on aqueous humor. It follows 3 mechanisms:-
1.) It increases aqueous humor outflow by increasing the pathway of uveoscleral.
2.) Ciliary body produces aqueous substance. This drug tends to decrease this production.
3.) It through trabecular mesh-work increases the outflow of aqueous product.

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