Advantages Of Vaginal Drug Delivery System
The female is more susceptible for vaginal infection like vaginitis and sexually transmitted disease (STD). This infections caused by Bacteria, Fungi, Virus, Parasites and Protozoa. The vaginal infection causing micro-organisms classified as follows,
Common Name and causing Micro-organism
a. Chancroid (Haemophilus ducreyi)
b. Chlamydia (Chlamydia trachomatis)
c. Granuloma inguinale (Klebsiella granulomatis)
d. Gonorrhea (Neisseria gonorrhoeae)
e. Syphilis (Treponema pallidum)
Candidiasis (yeast infection)
Common Name and causing virus
a. HIV (Human Immunodeficiency Virus)
b. HPV (Human Papilloma Virus)
c. Molluscum contagiosum (molluscum contagiosum virus MCV)
d. Viral hepatitis (Hepatitis B virus)
a. Crab louse(Pthirus pubis)
b. Scabies (Sarcoptes scabiei)
a. Trichomoniasis (Trichomonas vaginalis)
The available treatment for vaginal infection is depend on oral route and parenteral route. Which is having several disadvantages to give relief from vaginal infection. The emerging route for treatment of vaginal infection is intravaginal drug delivery system. The vaginal route of drug administration offers advantages over other routes such as the avoidance of hepatic first-pass metabolism, reduction in the incidence and severity of side effects within the gastrointestinal tract (GIT), and reduction in hepatic side effects of steroids used in hormone replacement therapy or contraception. The vaginal route overcomes the inconvenience caused by pain, tissue damage and possible infection by parenteral routes compared to the oral route, the vagina might prove better for the delivery of hormonal contraceptives due to a lack of drug interactions often encountered in the GIT.
Another advantage is the possibility for self-administration of single-dose drug delivery systems that may suffice in releasing drugs over a period of weeks or months and simultaneously provide optimal drug pharmacokinetic profiles. Further advantages with vaginal administration include convenient access, prolonged retention of formulations, an extensive region for drug permeation, high vascularisation and relatively low enzymatic activity. Therefore, intravaginal drug delivery has exploitable advantages compared to other routes of administration in the area of bioavailability and controlled drug delivery.
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