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Human genomes changes with age
Posted Date: 26 Jun 2008 Resource Type: Articles/Knowledge Sharing Category: General
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Posted By: Gayathtiri Raghunathan Member Level: Bronze
Rating:  Points: 2
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HUMAN GENOMES CHANGES WITH AGE
Individual human genomes change throughout a person’s life influenced by environmental or nutritional factors which may explain why illness such as cancer come with age, a study has claimed. Researchers at John Hopkins University found that the so-called epigenetic marks on the sequence of a person’s DNA modify over the course of their life and the extent of such changes is similar among family members.
“We’re beginning to see that epigenetics stands at the centre of the modern medicine because epigenetic changes. Unlike DNA sequence which is the same in every cell, can occur as a result of dietary and other environmental exposure,” said Andrew Feinberg, professor of molecular biology and genetics at the university. “Epigenetics might very well play a role in diseases like diabetes, autism and cancer,” he added in the study published in the Journal of the American Medical Association. The team analyzed the DNA sequences from 600 people taking part in the AGES Reykjavik study, formerly called the Reykjavik Heart Study in Iceland.
The participants supplied DNA samples in 1991, and then again between 2002 and 2005. Scientists then measured the variations in the level of methylation, which is the main epigenetic modification, in 111 samples. In about a third of cases, the methylation levels had changed over the years.
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