My Profile
Active Members
TodayLast 7 Days
more...
Awards & Gifts
Online Exams
Fresher Jobs
Our fresher job section is exclusively for fresh graduates! Find jobs for freshers in major Indian
cities including Bangalore, Chennai, Hyderabad, Pune or Kochi
Resources
Find educational articles, blogs, discussion threads and other resources.
Colleges
Find details about any college in India or search for courses.
|
BIOSYNTHESIS OF CYANOCOBALAMIN (VITAMIN B12) BY ACTIONMYCETES
Posted Date: 28 Jul 2008 Resource Type: Articles/Knowledge Sharing Category: Education
|
Posted By: K.Vijaya Bhaskar Member Level: Bronze
Rating:  Points: 1
|
|
|
Vitamin B12 (Cyanacobalamin) is an important water soluble vitamin. In constant to other water soluble vitamins it is not excreted quickly in the urine but, rather accumulates and is store in the liver, kidney and other body tissues. Vitamin B12, functions as a methyl donor and donor and works with folic acid in the synthesis of DNA and red blood cells and is vitally important in maintaining the health of the insulation sheath (myelin sheath) that surrounds nerve cells. The classical vitamin B12 deficiency disease is pernicious anaemia, a serious disease characterized by large, immature red blood cells. Vitamin B12 is important for the normal functioning of the brain and nervous system. Cyanocobalamin is a compound that is metabolized to a vitamin in the B complex commonly known as Vitamin B12. The biosynthesis of this essential nutrient is intricate, involved and remarkably confined to certain members of the prokaryotic world; seemingly nerve have to have made the eukaryotic transition.
Since 1948 a number of surveys have been made in which actinomycetes, particularly those of the Streptomyces genus have been reported as good producers of the vitamin B12. That a humble microorganism can construct a molecule having the complexity of vitamin B12 the antipernicious anaemia vitamin is quite amazing. An attempt was made in the present study to understand biosynthesis of cyanocobalamin by newly isolated strains of actionmycetes in general and Streptomyces sps. in particular. Five isolates of actinomycetes, including two novel strains of Streptomyces namely S. gulbargensis and S. tritolerans were examined for the biosynthesis of cyanocobalamin, as per the standard protocol by following bioassay method with L. delbrueckii subsp lactis ATCC7830. The biosynthesis of cyanocobalamin was found to be quite high in an isolate of actionmycetes DVB1 and in a novel strain S. gulbargensis. Further, biosynthesis of cyanocobalamin by all the test isolates in cup plate assay is in progress.
|
Responses
|
No responses found. Be the first to respond and make money from revenue sharing program.
|
|
Watch TV Channels
|