509111 Bioprocess Engineering
Teaching scheme Examination Scheme
Lecture: - 3h/week Theory: - 100 Marks
Advance Enzyme Kinetics: Models for complex enzyme kinetics, modeling of effect of pH and
temperature, models for insoluble substrate, models for immobilized enzyme systems, diffusion
limitations in immobilized enzyme system, electrostatic and steric effects.
How cell work- the central dogma, DNA replications, sending the messages, genetic code,
translation, posttranslational processing, sensing of extra cellular environment, roll of cell
Major metabolic pathways, bioenergetics, Glucose metabolism, metabolism of nitrogenous
compounds, respiration, metabolism of hydrocarbons, anaerobic metabolism, autotrophic
Bioreactors: modifications of batch and continuous reactors, chemostat with recycle, multistage
chemostat, fed-batch operation, perfusion system, active and passive immobilization of cells,
diffusional limitations in the immobilized system, solid state fomenters.
Homogeneous and heterogeneous reactions in bioprocesses: reaction thermodynamics,
growth kinetics with Plasmid instability, The Thiele Modulus and effectiveness factor, diffusion
and reaction in waste treatment lagoon. Reactors and choice of reactors.
Biological waste water treatment : microbial participation in natural cycle of matter, activated
sludge process, design and modeling of activated sludge process, Nitrification, anaerobic
digestion, mathematical modeling of anaerobic digester, anaerobic denitrification, phosphate
1) Biochemical Engineering Fundamentals – J. E. Bailey and D. F. Ollis – McGraw-Hill
2) Bioprocess Engineering Principles – P. M. Doran – Academic Press
3) Bioprocess Engineering – M. L. Shuler, F. Kargi , Prentice -Hall
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