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316284: Immunology
Teaching Scheme: Exam Scheme:
Theory: 4 hr/week Paper: 100 Marks
Practical: 2 hr/week Oral: 50 Marks
UNIT 1 [9 Hrs]
Overview of immune system, innate and adaptive immunity, Physiological barriers against
infection, phagocytosis, inflammation, humoral immunity, Cells and organs of immune
system,
UNIT 2 [9 Hrs]
Antigens, Structure and function of antibody, Activation of B cells, theories of antibody
production- clonal selection theory, organization and expression of Ig genes, generation of
antibody diversity, antigen antibody interactions- principles and applications, cross reactivity,
precipitation, agglutination, RIA, ELISA, Western blotting
UNIT 3 [9 Hrs]
Cell mediated immunity, Major Histocompatibility Complex (MHC), graft rejection, GVH,
antigen processing and presentation, T cells
UNIT 4 [9 Hrs]
Immune effector mechanisms, cytokines, complement system, cell mediated effector
responses, cytotoxic T cells, Natural killer cells, ADCC, hypersentitive reactions- allergen,
reaginic antibody, Type I-IV reactions
UNIT 5 [9 Hrs]
Vaccines, active and passive immunization, attenuated vaccines, role of adjuvants, anti-sera,
immunoglobulins, toxoids, recombinant vaccines, subunit vaccines, DNA vaccines
UNIT 6 [9 Hrs]
Immune system in diseases, autoimmunity, cancer and immune system, TB,
Immunodeficiency, AIDS
Practical
1. Quantitation detection of immunoglbulin using precipitation reaction
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2. Haem-agglutination
3. Determination of antibody titer by Radial Immuno Diffusion (RID)
4. Ouchterlony Immunodiffusion for detection of antigen/ antibody-Titration
5. ELISA
6. Western Blotting
Text Books
1. Kuby- Immunology (4th Edition) by R. A. Goldsby, T.J. Kindt, B.A. Osborne.
Reference Books
1. Essentials of Immunology (6th Edition): Ivan Riot- Blakswell Scientific Publications,
Oxford, 1988
2. Fundamentals of Immunology: Paul W.E. (Eds.) Raven Press, New York, 1988.
3. Antibodies A laboratory Manual: Harlow and David Lane (1988), Cold spring harbor
laboratory.
For more details, visit http://www.unipune.ernet.in/stud_info/Syllabi/Syllabus_2008.html
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