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JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY
HYDERABAD
III Year B. Pharmacy II-Semester T P C
0 3 2
(R7509) PHARMACOLOGY – II LAB
1. Introduction to Experimental Pharmacology
Preparation of different solutions for experiments.
Drug dilutions, use of molar and w/v solutions in experimental Pharmacology.
Common laboratory animals and anesthetics used in animal studies.
Commonly used instruments in experimental pharmacology.
Some common and standard techniques.
Bleeding and intravenous injection, intragastric administration.
2. Experiments on intact preparations:
Study of different routes of administration of drugs in mice/rats.
3. Experiments in Central Nervous system:
Recording of spontaneous motor activity, stereotype, analgesia, anticonvulsant activity, anti inflammatory activity,
4. To study the effect of autonomic drugs on rabbit’s eye
5. To study the effects of various agonists and antagonists and their characterisation using isolated preparations like frog's rectus abdominus muscle and isolated ileum preparation of rat& guinea pig.
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| Author: India 29 Dec 2007 | Member Level: Diamond Points : 5 |
Experiments on Isolated Preparations:
i. a. To record the concentration response curve (CRC) of acetylcholine using rectus abdominus muscle preparation of frog.
b. To study the effects of physostigmine and d tubocurarine on the crc of acetylcholine using frog rectus abdominus muscle preparation of frog.
c. To record the CRC of 5 HT on rat fundus preparation.
d. To record the CRC of histamine on guineapig ileum preparation.
ii. a. To study the inotropic and chronotropic effects of drugs on isolated frog heart.
b. To study the effects of drugs on normal and hypodynamic frog heart.
6. Experiments pertaining to analgesia, anti-convulsant activity, anti-
inflammatory activity (Only demonstration).
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