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JNTU 2007-08-IV Year-II-Sem-B-Pharmacy-MEDICINAL CHEMISTRY – III
Posted Date: 29 Dec 2007 Resource Type: Articles/Knowledge Sharing Category: Syllabus
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Posted By: India Member Level: Diamond
Rating:  Points: 1
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JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY
HYDERABAD
IV Year B. Pharmacy II-Semester T P C
3+1* 0 3
(R7703) MEDICINAL CHEMISTRY – III
Note:
A study of the following classes of drugs including introduction, classification with examples of structures, mechanism of action, SAR and metabolism. Synthesis of compounds specified against each class is to be studied for the following UNITS
UNIT – I
Drugs acting on Cardio-vascular diseases:
General account of cardiovascular diseases
Antihypertensives – Methyldopa, amlodipine, enalapril, losartan.
UNIT – II
Anti-arrhythmics – Procainamide
Diuretics – Acetazolamide, hydrochlorthiazide, furosemide
Anticoagulants, Anti-anginals and Coronary vasodilators – Isosorbide dinitrate, verapamil, diltiazem
UNIT – III
Antihyperlipidemics (Hypocholesteremic drugs)- Clofibrate. A brief account on statins
General account on pancreatic and thyroid hormonal malfunctions.
Antidiabetics – Phenformin, Glipizide including a brief account on PPAR inhibitors, Meglitinide analogues,
?-Glucosidase inhibitors – Acarbose, Miglitol
Drugs affecting Thyroid Function: Methimazole, Propylthiouracil, Insulin preparations
UNIT – IV
Analgesics and NSAIDS (Non-steroidal anti-inflamatory agents):
i. Introduction and types of pain and inflammation
ii Classification and systematic development of analgesics of morphine, mild analgesics and strong analgesics: Meperidine and Methadone
iii. NSAIDS – Aspirin, paracetamol, oxyphenbutazone, ibuprofen, indomethacin, diclofenac and meloxicam
iv. A brief account on Cox-2 inhibitors and Nimsulide.
UNIT – V
Chemotherapeutic Agents:
Sulpha drugs - Sulphadiazine, Suphasalzine, Trimethoprim, Sulphamethoxazole, Sulphameter
Anti viral Drugs - Acyclovir, Zidovudine
Antifungal Agents - Fluconazole and Itraconazole.
UNIT – VI
Anti tubercular agents : Isonicotinic acid hydrazide and ethambutol,
Anti leprotic agents : Dapsone, clofazemine
Antiamoebics : Metronidazole, diloxanide furoate
UNIT - VII
Anthelmintics : Diethylcarbamazine citrate, pyrantel pamoate,
mebendazole, albendazole
Antimalarial drugs : Chloroquine, primaquine and pyrimethamine, norflaxacin and ciprofloxacin
UNIT – VIII
Anticancer Drugs : Chlorambucil, busulphan, procarbazine, carmustine, 5-flurouracil, 5-mercaptopurine methotrexate, vinca alkaloids – vinblastin, vincristine
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| Author: India 29 Dec 2007 | Member Level: Diamond Points : 5 | TEXT BOOKS
1. William O. Foye, Textbook of Medicinal Chemistry by, Lea Febiger, Philadelphia.
2. JH Block & JM Beale, Wilson & Giswold’s Textbook of organic Medicinal Chemistry and pharmaceutical chemistry by (Eds), 11th Ed, Lipcott, Raven, Philadelphia, 2004.
3. S. N. Pandeya, Textbook of mediacinal chemistry, SG Publ. Varanasi, 2003.
4. Rama Rao Nadendla, Medicinal Chemistry.
REFERENCES
1. D. Abraham (Ed), Burger Medicinal chemistry ad Drug discovery, Vol. 1 & 2. John Wiley & Sons, New York 2003, 6th Ed.
2. Lippincott Williams and Wilkins: Remington Pharmaceutical Sciences
3. L. M. Atherden, Bentley and Driver’s Textbook of Pharmaceutical Chemistry. Oxford University Press, Delhi.
4. B.N. Lads, MG.Mandel and F.I. way, Fundamentals of drug metabolism & disposition, William & welking co, Baltimore USA.
5. C. Hansch, Comprehensive medicinal chemistry, Vol 1 – 6 Elsevier pergmon press, oxford
6. Daniel lednicer, Strategies For Organic Drug Synthesis And Design, John Wiley, N. Y. 1998.
7. D. Lednicer, Organic drug synthesis, Vol, 1 – 6, J.Wiley N.Y.
| | Author: India 29 Dec 2007 | Member Level: Diamond Points : 5 | BOOKS RECOMMENDED (PHARMACEUTICAL ANALYSIS, PHARMACEUTICAL CHEMISTRY BIOCHEMISTRY)
J Bassett, R C Denny, G H Jeffery, J Mendham, Vogel’s Text book of quantitative Inorganic analysis, ELBS/Longman, London.
L M Atherden, Benteley and Driver’s Text book of Pharmaceutical Chemistry, oxford university Press , London
L M Kothoff and V A Stenger, Volumetric analysis, Vol.II Titration methods, Interscience Publishers, INC., new York
Pharmacopoea of India, Government of India, Ministry of Health
L G Chatten, A Text book of Pharmaceutical Chemistry, VolI and II, Marcel Dekker, New York.
A H Beckett and J B Stenlake, Practical Pharmaceutical Chemistry Vol. I and II. The athlone press of the university of London.
A M Knevel and FE Digani, Jenkin’s Quantitative Pharmaceutical Chemistry, McGraw Hill Book Co., New York.
J H Block, F Roche, I O Soine and C O Wilson, Inorganic Medicinal and Pharmaceutical Chemistry, Lea and Febiger, Phildelphia, P A.
L A Disheher, Modern Inorganic Pharmaceutical Chemistry
W S Brey, Physical Chemistry and its biological applications Academic Press.
K J Laidler, Physical Chemistry with Biological applications, Benjamin
V R Williams and H S Williams, basic Physical Chemistry for the life sciences, W H Freeman
S R Pali and S K D E Prabartak, practical Physical Chemistry, Haltone Limited, Calcutta.
D P Shoemaker, C W Garland, Experiments in Physical Chemistry, McGraw Hill Book Co., New York.
J A Ritchener, Findley’s physical chemistry, (Ed) Green & Co., London
A N Acheson, An Introduction to the chemistry of heterocyclic compounds, Interscience Publication, New Delhi.
P Sykes, A guidebook to mechanism in organic chemistry, Orient Longman, New Delhi.
J D Roberts and M C Caserio, Basic principles of Organic Chemistry, W A Benjamin, Inc ., New York.
I L Finar, Organic Chemistry, Vol. I., The Fundamentals of Principles, ELBS/Longman
F C Mann, and B C Saundes, practical organic chemistry. The English language book society and long man group limited, London.
A I Vogel, A text book of practical organic chemistry. The English language society and longman group limited, London.
E L Eliel, Stereochemistry of carbon compounds, Mc Graw Hill book company, Inc., New York
B.S Furniss, A J Hannaford, P W G Smith and A R Tatehell vogel’s Text boook of practical organic chemistry. The ELBS/Longman, London
D T Plumer., An Introduction to practical biochemistry, Tata McGraw Hill, New Delhi
J Jayaraman, laboratory manual in Biochemistry, Willey Estern Limited, New Delhi
D W Martin, P A Mys and V M Redwell, Harpers Review of Biochemistry, lange Medical Publications.
E E Conn and P K Stumpf, Outlines of biochemistry, John Willey and sons, New York.
A L Lehninger, Biochemistry, Worth Publisher, Inc.,
A L Lehninger, Principles of Biochemistry, CBS Publishers and Distributors
L Stryer, Biochemistry, W H Freeman and Company, Sanfransisco
B Harrow and A Mazur, Text Book of Biochemistry, W B Saunders Co., Philadelphia.
C Hanch, Comprehenisve medicinal chemistry, Vol. IV, quantitative Drug Design, Pergamon Press. Oxford
V.C. Martin, quanititative Drug Design – Critical Introduction (Medicinal Research Monographah, Vol. 8 Marcel Dekker, Inc. New York
Exploring QSAR : Vol. I Fundamentals and applications in chemistry and biology and C Hanch, A Leo and D Hockman ACS Book Catalog.
P C Jurs, Computer software application in chemistry, John Wiley & Sons, New York.
M E Wolff, Ed. Burger’s Medicinal Chemistry, John Wiley & New York
J N Delagado and W A R Remers, Eds., Wilson and Gisworld’s Text book of Organic Medicinal and pharmaceutical chemistry, J Lipponcott Co., Philadelphia
W C Foye, principles of Medicinal Chemistry, Lea & Febiger, Philadelphia 1955
T Nogrady, Medicinal Chemistry – A Biochemical Approach. Oxford University Press, New York, Oxford
B.N.Ladu, H G Mandel and E L Way., Fundamentals of Drug Metabolism and Disposition, William and Welkins Co., 428 E, Preston street, Baltimore
J E F Reynolds, Martindale, The Extra Pharmacopoea, The pharmaceutical press, London
J E F REYNOLDS, Martindale, The Extra Pharmacopoea, The Pharmaceutical Press London
Analytical Chemistry – Y. ANJANEYULU - Pharma Book Syndicate.Hyderabad.
T Nogrady, Medicinal Chemistry – A Biochemical Approach.- Pharma Book Syndicate. Hyderabad.
OTHER BOOKS RECOMMENDED
Popst and Perrum “Computer Aided Drug Design”. Academic Press, New York.
Computer Programming in pascal – V Ragaraman, Prentice – hall of India New Delhi, 1983.
Computers and Commonsense – N Hunt and J Shelley, prentics – Hall of India, New Delhi, 1981.
PASCAL USER MANNUAL AND Report – K Jensen and N Wirth., Narosa Pub. House, New Delhi, 1983.
Systematic programming in Introduction – N Wirth, Prentice Hall Englewood cliff’s New Jersey, 1973.
Programming in Pascal – P Grogona, Adeison Wesley, Reading, M.A., 1980.
Text Book of Drug design and discovery 3/Edn.- LARSEN.- Pharma Book Syndicate.
Name Reaction: LI - Pharma Book Syndicate. Hyderabad.
Organic Reaction Mechanisms – GALLEGO- Pharma Book Syndicate.Hyderabad
Text book of Forensic Pharmacy – KOKATE - Pharma Book Syndicate.Hyderabad.
The art of writing Reason. Organic REAC.MECH – GROSS MAN - Pharma Book Syndicate.Hyderabad.
Hand Book of Instrumental Techniques for Analytical Chemistry – SETTLE - Pharma Book Syndicate. Hyderabad.
Quality Assurance and Quality Management in Pharma Industry –Y. ANJANEYULU, R. MARRAYA, - Pharma Book Syndicate.
What Everyone should know about PATENTS.- SUBBA RAM - Pharma Book Syndicate
Elementary BioInformatics – KHAN - Pharma Book Syndicate.
Analytical Chemistry – Y. ANJANEYULU - Pharma Book Syndicate.Hyderabad.
Phytochemical Methods by HARBONE, Published by Chapman & Hall
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