Metronidazole is a drug from imidazole group.
Uses of Metronidazole
Metronidazole is used in
1. Anaerobic infections
2. Protozoal infections - Amoebiasis
3. Vaginitis due to Trichomonas
4. The post-natal period for the treatment and prophylaxis of infection following Caesarian section
5. Post-partum haemorrhage and other complications of childbirth in which infection is a possible hazard.
6. Dental infections
7. Mouth ulcer
8. Abdominal infections
Topical metronidazole for acne rosacea and mouth ulcers. Its available as metronidazole gel and Metronidazole DS gel.
Other drugs in this group
Whether metronidazole and hydroxymetronidazole gets secreted in breast milk?
The risk to the infant due to the mutagenic activity of the drug was a cause of concern. But metronidazole therapy for breast-feeding mothers is now proven to be safe.
Metronidazole gets excreted in milk at concentrations which causes no serious reactions in the infants. So the drug may be administered at doses of 400 mg three times daily to breast-feeding mothers. Studies have proven that there was no significant increase in adverse effects in infants which could be due to maternal metronidazole therapy.
Side effects of metronidazole
1. Metallic taste – This is a very annoying side effect
Brand names with which metronidazole is available?
It is available in tablet and intravenous drug form.
Interaction with alcohol
This is really interesting. If a patient on metronidazole consumes alcohol, a disulfiram-like reaction is seen. What is this? Patient gets -
1. Increased heart rate
2. Gastrointestinal disturbances in the form of nausea, vomiting
3. Difficulty in breathing
How to avoid disulfiram-like reaction?
Avoid consuming alcohol when on metronidazole and within 2 days after completing Rx.