BIOPROCESS PRINCIPLES




UNIT I OVERVIEW OF FERMENTATION PROCESSES 12
Fermentation process – Medium requirements – Medium formulation of optimal growth and product
formation – Simple and complex media – Design of various commercial media for industrial
fermentations – Microbial growth – Applications of fermentation – Microbial biomass – Microbial
metabolites – Microbial enzymes – Transformation process – Recombinant products – Main
parameters in fermentation processes – Mode of operation of fermentation processes – Basic
configuration of fermenter and axillaries.
UNIT II KINETICS OF IMMOBILIZED ENZYMES AND STERILIZATION 12
Methods of immobilization – Kinetics of immobilized enzymes – Thermal death kinetics of
microorganisms – Batch and continuous heat sterilization of liquid media – Filter sterilization of
liquid media – Air sterilization and design of sterilization equipment.
UNIT III METABOLIC STICHIOMETRY AND ENERGITICS 12
Stoichiometry of cell growth and product formation – Elemental balances – Degrees of reduction of
Substrate and Biomass – Available Electron Balances – Yield coefficients of Biomass and Product
formation – Maintenance coefficients energetic analysis of microbial growth and product formation –
Oxygen consumption and heat evolution in aerobic cultures – Thermodynamic efficiency of growth.
UNIT IV KINETICS OF MICROBIAL GROWTH AND PRODUCT FORMATION 12
Modes of operation – Batch, Fed Batch and Continuous Cultivation – Simple unstructured kinetic
models for microbial growth – Monad model – Growth of filamentous organisms – Product formation
kinetics – Leudeking-piret models, substrate and product inhibition on cell growth and product
formation.
UNIT V OPTIMIZATION METHODS 12
Overview of response surface methodology – Factorial design – Central composite design – Three
level design – Plackett-Burman design and Taguchi design of experiments.
L: 60 Total: 60
TEXT BOOKS
1. Stanbury P. F., Hall S. J. and Whitaker A., “Principles of Fermentation Technology”, Science
& Technology Books, 1999.
2. Blanch H. W. and Clark D. S., “Biochemical Engineering”, CRC Press, 1997.
REFERENCES
1. Anderson M.J. and Whitcomb P.J., “RSM Simplified: Optimizing Processes Using Response
Surface Methods for Design of Experiments”, Productivity Press, 2005.
2. Jack P.C. Kleijnen, “Design and Analysis of Simulation Experiments”, Springer, 2008.
3. Roy R.K., “Design of Experiments Using the Taguchi Approach: 16 Steps to Product and
Process Improvement”, Wiley-IEEE, 2001.
4. Shuler M.L. and Kargi F., “Bioprocess Engineering: Basic Concepts”, Second Edition,
Prentice Hall, 2001.


Related Articles

Indian Premier League (IPL), show of BCCI's might

This article is about Indian Premier League (IPL), the brand sporting event organised by BCCI. This article reveals about the IPL's extragavancy and obviously the magnitude of money involved in the league which is known for its high magnitude entertainment. This article gives a clear picture about how the IPL make BCCI, franchise bank balances green, sponsors and the brand value of each team.

Time schedule of IPL 2012

In this article I am presenting the time schedule and time table of Indian Premier League IPL 2012. Four seasons of Indian premier league has passed now the time of IPL session 5 at April 4th. The first match between Chennai Super Kings v Mumbai Indians M.A. Chidambaram Stadium, Chennai.

IPL-5 auction news makers

This article deals with the interesting features of IPL-5 auctions held at Bengaluru on Saturday, the 4th of February 2012. The top pick of the IPL-5 was Ravindra Jadeja who bagged $2m (Rs.9.71crore). He is bought by Chennai Super Kings in a tie breaker with Deccan Chargers. 8 teams bid for 25 players. Mumbai Indians and Rajasthan Royals had maximum buys with 5 players each. The article names the top 5 picks of the IPL-5. The names of all the 25 players and the teams which bought them are given.

Indian Premier League 6 (IPL 6) 2013- Schedules and latest grasps

DLF IPL 6 is coming soon, live in stadium and on Sony Max at homes. Here is an article about the schedules, ticket booking and latest grasps from IPL 6 2013. This article also contains a short review of 1-5 IPLs played in last 5 years. This article is relates "Indian Premier League 6 (IPL 6) 2013- Schedules and latest gasps".

More articles: Ipl

Comments

No responses found. Be the first to comment...


  • Do not include your name, "with regards" etc in the comment. Write detailed comment, relevant to the topic.
  • No HTML formatting and links to other web sites are allowed.
  • This is a strictly moderated site. Absolutely no spam allowed.
  • Name:
    Email: