Asthma & its Complication




Asthma is known as inflammatory condition in which Airways get swollen results in narrower & less air pass through to the lung tissue. Symptoms like wheezing, coughing, chest tightness, trouble in breath, etc.
The asthmatic attack observed when chronic inflammation of airways that increases mucous secretion results in very narrower space for breath. Some time people can die with severe asthmatic attack. If we will not take precaution for asthma it alters our life style.
Pathophysiology: the main reason for asthma is inflammation, but in such cases not well understood why airways narrow? It may be genetical. Inflammation is due to allergic conditions that gives inflammation & narrows the airways. When person contact with allergen then he suffered from inflammation that leads to antibody-antigen reactions. In which certain mediator’s releases like histamine, leukotrienes, etc. which responsible for asthma.
Triggers of asthma; the average persons triggered asthma change in conditions
Air pollution: is trigger for 4 out of 10 people.
Cold air: is trigger for 6 out of 10 people.
Cigarette smoke; is trigger for 7 out of 10 people.
House dust; is trigger for 7 out of 10 people.
Animal west: is trigger for 8 out of 10 people.
Viral infection: is trigger for 8 out of 10 people.
Treatment:
Inhaled Beta agonist: albuterol
Leukotriene modifiers: Montelukast, zafirlukast
Cromolyn & nedocromil
Theophylline: Methyl xanthine
Inhaled Glucocorticoids: Beclomethasone, Fluticasone


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